一新研究证实对男性生育能力的影响

写作者: Hibz Y.D.

链接：

根据发表在FASEB杂志上的一项一新研究成果，也意味著对成年人胎盘转化成毒害作用。

一项本意在于提高成年人生育能力的研究成果辨认出一种叫做CB2的素激素与胎盘生成的反复有关。研究成果其他部门解读说，这一辨认出表明，意味著亦会破坏成年人的生育能力。

由意大利海德堡大学Paola Grimaldi领导的研究成果团队让实验小鼠口服不同的药物，其中一组口服CB2激素的活化剂，另一组则口服CB2激素酶抑制剂，第三组作为对照组只口服生理盐水。研究成果试验中，口服CB2活化剂的小鼠有更快的生精速亲率，而口服CB2酶抑制剂的小鼠则显示了相反的缺点并有较慢的胎盘转化成亲率。这些试验中，CB2的激活并不需要可维持一定的平衡状态以保证正确的胎盘转化成反复。

FASEB杂志的总编Thoru Pederson指出，这项研究成果有意味著为成年人不育症的化疗开辟一属于自己研究成果方向。他还说：“内源性素对胎盘正常人转化成亦会有正面缺点，如果换用可以大幅度感受到这种缺点的激动剂，有意味著发展出化疗成年人不育症的一些一新疗法”。

Marijuana Can Affect Male Fertility, Suggests New Study

The study focusing mainly on finding ways to enhance male fertility has found that a ‘marijuana receptor’ called CB2 (a cannabinoid receptor) is linked with the regulation of sperm production (a process named spermatogenesis). This might sound like good news, but the researchers of the study explain that this finding indicates that marijuana might thus be disrupting male fertility.

Led by Paola Grimaldi from the University of Rome Tor Vergata, Italy, the team treated mice with different agents: one group, with an activator of the CB2 receptor; another with an inhibitor of the same receptor; a third group acting as the control one received only a saline solution.

The findings show that the CB2 activator group had a more rapid rate of spermatogenesis while the inhibitor group displayed the opposite effect as they had a slower rate of sperm production. These results suggest that CB2 activation is needed to be in a certain balance for spermatogenesis to occur properly and adequately.

This research might be opening up new doors for the treatment of male infertility, as pointed out by the Editor-in-Chief of The FASEB Journal, Thoru Pederson. According to the latter, “the normal beneficial effects of endogenous cannabinoids on spermatogenesis can be stimulated further by a chemical mimic, an agonist, is a potentially promising new idea for treating male infertility“.

（文中来自沈阳九州家圆医院官方网站）